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Clinical Trials of Aeknil Injection by
Medical & Civil Hospital, Ahmedabad
 

 


Table 3: RESULTS

 

 Result

 Paracetamol

Analgin

Oral

 GOOD

 48 (64%)

 32 (64%)

 4 (33.3%)

 FAIR

 19 (25.3%)

 11 (22%)

 2 (16.7%)

 POOR

 8 (10.7%)

 7 (14%)

 6 (50%)

In 89.3% the response in lowering the temperature was satisfactory. The temperature was brought to normal within 2 hours. The results with Injection Analgin are also identical. The Oral administration has been useful in only 50% of the cases.

 

The relationship of effect of different antipyretics in the same disease is put up in Table 4:

Table 4 

Relationship between the type of illness to response
 

G = Good       F = Fair          P = Poor

 

 

PARACETAMOL

 ANALGIN

 ORAL

 G

 F

 P

G

 F

 P

 G

F

P

Tuberculosis

 6

 4

 2

 6

 3

2

1

1

1

Pneumonia

4

3

0

-

-

-

0

0

1

Tetanus (including neonatal tetanus)

7

2

2

2

3

1

-

-

-

Bronchiolitis

1

2

0

3

-

-

-

-

-

Enteric Fever

7

3

1

6

2

0

-

-

1

Acute Gastroenteritis

8

1

1

5

-

1

1

-

1

Food Poisoning

1

-

-

-

-

-

-

-

-

Bronchiectasis

2

-

-

1

-

-

-

-

-

Encephalitis

0

1

1

-

1

1

-

-

-

Pyogenic Meningitis

1

-

-

1

-

-

-

-

-

Nonspecific Undefined P.U.O

11

3

1

8

2

2

2

1

2

Total

48

19

8

32

11

7

4

2

6


In some cases when the pyrexia did not respond to one antipyretic or recurred after sometime, another antipyretic was used and the effects noted are recorded in Table 5.
 

Table 5 

G = Good       F = Fair          P = Poor 

 Group

Cases

Response

 Paracetamol (Aeknil)

 Analgin

   

 8

Paracetamol (Aeknil)

Analgin

G (3)

F (2)

P (3)

G (4)

F (3)

P (1)

 Analgin

Paracetamol (Aeknil)

11

Analgin

Paracetamol (Aeknil)

 G (5)

 F (2)

 P (4)

G (8)

F (1)

P (2)

 Oral

Paracetamol (Aeknil)

1

Oral

Paracetamol (Aeknil)

-

 -

P (1)

G (1)

-

-

 Oral

Analgin

Paracetamol (Aeknil)

  3

 Oral

 Analgin

 Paracetamol (Aeknil)

 P (3)

 G (2)

 F (0)

P (1)

G (2)

F(0)

 P(1)

 Analgin

Paracetamol (Aeknil)

Oral

 2

 Analgin

 Paracetamol (Aeknil)

 Oral

 -

-

 P (2)

 -

F (1)

P (1)

P (2)



Considering the Good and Fair response, the average time taken to bring down the temperature to normal was noted in Table 6:


Table 6 

AVERAGE TIME
 

N-Acetyl Para Amino Phenol (Paracetamol)

2 hours 12 minutes

 Analgin

 2 hours 25 minutes

 Oral

2 hours 30 minutes

No toxic reactions were encountered in any of these patients, either to Injectable or to Oral therapy.

 

1 2 3 4 5


 

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