|
Therefore the main
aim in the therapy of fever is
diminution of fever and correction
of side effects caused by the
diminution of fever. The main side
effects are:
-
Peripheral Circulatory Failure
-
Dehydration
The
principles of therapy of fever are
as follows:
-
By causing more loss of heat
-
By causing less production of
heat
-
By depressing the thermostat at
a lower level
More
loss of heat can be achieved by:
-
Cooling of the body surface
-
Hypothermia induction
Less
production of heat can be achieved
by the specific action of certain
food on drug, which is practically
impossible.
Depression of the thermostat at a
lower level can be achieved by
various drugs. Such as:
|
1. |
Salicylates
and it’s derivatives |
|
|
2. |
Para Aminophenol
derivatives |
a)
Phenacetin |
| |
|
b)Acetaminophen
(Paracetamol) |
| |
|
c)Acetanilid |
|
3. |
Pyrazolone
derivatives |
a)Antipyrine |
| |
|
b)Amicopyrine |
|
4. |
Quinolone
derivatives Quinine |
a)Phenylbutazone |
|
5. |
Mone
Addicting Opioide |
|
|
6. |
Other Organic Acid |
a)Indomethacin |
| |
|
b)Mefenamic
Acid |
| |
|
|
Induction of Hypothermia is
done in the following way:
Method 1: Hypothermia produced
by the cooling of the body
surface
Method 2: Hypothermia with
Cardiac by-pass
In the first method application
of the packs to the unprotected
surface of the body, the use of
mattress, through which
ice-water may be circulated or
the total immersion of the body
in a cooled cabinet (Fossester
et al, 1961) are simple and
effective methods of lowering
the temperature. the protective
reflexes as shivering and
vasoconstriction must be
controlled. Shivering visible or
invisible increase metabolic
activity with increased oxygen
demand resulting in techycardia.
Pituitary adrenal stress results
more heat production and slows
down the cooling process.
Vasoconstriction delays the
cooling by little perfusion the
cold tissue. These things can be
inhibited by deep anaesthesia,
chlopromazine and others.
|
